Putting ethics before profits on Covid-19 cure

Sheikh Abdullah bin Mohammed Al Hamed, chairman of Department of Health, Abu Dhabi, is being administered the world’s first clinical Phase III trial of inactivated vaccine to combat Covid-19.

As Covid-19 surges in the United States and worldwide, even the richest and best insured Americans understand, possibly for the first time, what it’s like not to have the medicines they need to survive if they get sick.

There is no coronavirus vaccine, and the best known treatment, remdesivir, only reduces hospital recovery time by 30 percent and only for patients with certain forms of the disease.

Poorer people have always had trouble accessing essential medicines, however—even when good drugs exist to prevent and treat their conditions.

In the US, where there is no legal right to health, insurance is usually necessary for medical treatment.

Remedesivir costs about $3,200 for a typical treatment course of six vials, though critics argue its manufacturer, Gilead, could make a profit off much less.

Internationally, high drug prices mean that critical medicines are often available only to the richest patients.

Access to medicines, in other words, is usually an ethical problem—not a scientific one. And that’s going to complicate the global coronavirus fight.

Experts worry that any Covid-19 vaccine is likely to have a high price tag and, as a result, be unequally distributed according to countries’ purchasing power, not need.

With a little imagination, this challenge can be overcome. My new book “Global Health Impact: Extending Access to Essential Medicines” documents how in past epidemics, from polio and Ebola to HIV, the international community managed to get lifesaving drugs to patients—no matter where they lived or how much they earned.

Past wins

It took years for scientists to identify an effective treatment for HIV. But by 1997, most people diagnosed with HIV in Europe and the US were living long and productive lives thanks to antiretroviral drugs.

Meanwhile, the disease was still killing 2.2 million people each year in sub-Saharan Africa because pharmaceutical companies claimed it was impossible to lower the $10,000 to $15,000 annual cost per patient for antiretrovirals.

In response, human-rights activists galvanized a global AIDS campaign, educating African patients about antiretrovirals, giving them the tools they required to demand treatment and even suing drug companies.

Eventually, mass protests erupted in South Africa and elsewhere, shifting public opinion on access to medicines.

By 2000, competition from generic drug manufacturers brought the price of antiretrovirals down to around $350 per patient per year, allowing millions more worldwide to take them.

Around the same time, a similar story was playing out with tuberculosis, which had greatly diminished in the US and Europe but remained deadly in many other places.

The rise of drug-resistant strains—especially in the former Soviet Union and parts of Africa and Asia—posed a particularly terrible challenge.

Conventional wisdom held that people with drug-resistant TB couldn’t be saved. The drugs were too expensive, treatment courses too long and disease management too complicated.

The organization Partners in Health disproved that excuse by successfully treating 50 tuberculosis patients in Peru, then one of the world’s poorest countries.

That project helped convince the World Health Organization to endorse multi-drug-resistant TB treatment. Global funding for TB treatment increased greatly and generic medicines were produced.

Today more than 70 percent of people diagnosed with drug-resistant TB receive treatment

Ending Covid-19 ethically

These health campaigns both demonstrate the virtue I call creative resolve, which is a fundamental commitment to overcoming apparent tragedy.

Other examples include the adoption of “ring vaccinations” in the 1960s—a contact tracing-based immunization strategy pioneered in the 1960s after mass vaccinations failed to stop smallpox—and a 2010 campaign to give children in Afghanistan their polio vaccinations at the circus.

Ending the global coronavirus pandemic will require similar creative resolve.

Recently, the US agreed to pay $1.2 billion for early access to a promising Covid-19 vaccine in the United Kingdom and secured first access to another by the French pharmaceutical company Sanofi, enraging citizens of those countries.

Such arrangements also harm manufacturing countries like Brazil, Egypt and India, whose people have little access to the medicines their factories pump out.

Unequal access to Covid-19 medicines isn’t just a moral problem. In a global pandemic, an outbreak anywhere threatens people everywhere.

There is some creative resolve on display in the Covid-19 fight, though.

For example, the Medicines Patent Pool—a United Nations-backed organization that encourages companies to share their patents in order to speed up innovation—is pushing this method for advancing the research and development of Covid-19 drugs.

Other health experts are proposing new medicine distribution mechanisms  that would send drugs and vaccines where they’re most needed based on the net health benefits a population would receive.

That plan and others require smart data use. The Global Health Impact Project, a research collaboration that I direct, measures the effectiveness and availability of lifesaving medicines.

The idea is that if we know which drugs are actually addressing pressing health needs and where, policymakers and health organizations can craft more targeted treatment access plans.

Such information could be also used creatively to reward drug companies for their global health impact.

Governments could create an international prize, say, that awards funds to companies based on the lives saved by their Covid-19 drugs and other essential medicines. That could offset profit as the primary motivation for drug research, development and sales.

And if pharmaceutical companies don’t voluntarily help people in poor countries, those governments can do what they’ve done in past health crises: let other companies produce generic versions of patented medicines, to protect the common good.

Nicole Hassoun/The Conversation

Image credits: AETOSWire via AP


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